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Carbonyldiimidazole

(2023-03-31 19:19:12) 下一个

1,1'-Carbonyldiimidazole (CDI) is an organic compound with the molecular formula (C3H3N2)2CO. It is a white crystalline solid. It is often used for the coupling of amino acids for peptide synthesis and as a reagent in organic synthesis.

 

CDI is mainly employed to convert amines into amidescarbamatesureas. It can also be used to convert alcohols into esters.

Acid derivatives

The formation of amide is promoted by CDI. Although the reactivity of CDI is less than acid chlorides, it is more easily handled and avoids the use of thionyl chloride in acid chloride formation, which can cause side reactions. An early application of this type of reaction was noted in the formation of peptide bonds (with CO2 formation as a driving force). The proposed mechanism for the reaction between a carboxylic acid and CDI is presented below.

Mechanism for CDI acid activation

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